Symbol
Name
ID

Adam17
a disintegrin and metallopeptidase domain 17
MGI:1096335

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

enhanced leukocyte tethering or rolling

enlarged spleen

myeloid hyperplasia

extramedullary hematopoiesis

increased bone marrow cell number

increased erythrocyte cell number

decreased hematocrit

increased hemoglobin content

increased neutrophil cell number

thrombocytosis

decreased B cell number

increased T-helper 1 cell number

increased T-helper 17 cell number

increased T-helper 2 cell number

decreased T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased leukocyte cell number

abnormal spleen morphology

increased spleen red pulp amount

increased IgE level

abnormal macrophage physiology

abnormal platelet physiology

Availability

Mouse Genotype

Adam17^tm1.1Srj/Adam17^tm1.1Srj

Adam17^tm1Imx/Adam17^tm1Imx

Adam17^tm1Rain/Adam17^tm1Rain

Adam17^{tm1a(EUCOMM)Wtsi}/Adam17⁺

Adam17^tm1.2Bbl/Adam17^tm1.2Bbl
Sox9^tm3(cre)Crm/Sox9⁺ (conditional)

Adam17^tm1Bbl/Adam17^tm1Bbl
Lyz2^tm1(cre)Ifo/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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